2014 ICD-9-CM Diagnosis Code 200.3 Show
Marginal zone lymphoma
Applies To
ICD-9-CM Volume 2 Index entries containing back-references to 200.3: ICD-9-CM codes are used in medical billing and coding to describe diseases, injuries, symptoms and conditions. ICD-9-CM 200.3 is one of thousands of ICD-9-CM codes used in healthcare. Although ICD-9-CM and CPT codes are largely numeric, they differ in that CPT codes describe medical procedures and services. Can't find a code? Start at the root of ICD-9-CM, check the 2014 ICD-9-CM Index or use the search engine at the top of this page to lookup any code. NoteIn outpatient care, the ICD code on medical documents is always appended with a diagnostic confidence indicator (A, G, V or Z): A (excluded diagnosis), G (confirmed diagnosis), V (tentative diagnosis) and Z (condition after a confirmed diagnosis). Advanced Search Help
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NameICD-O-3 MorphologyEffective 2001 and later Reportablefor cases diagnosed 2001 and later Primary site must be spleen (C422) Help me code for diagnosis year :Abstractor NotesDiagnostic ConfirmationThis histology can be determined by positive histology (including peripheral blood) with or without genetics and/or immunophenotyping. Review the Definitive Diagnostic Methods, Immunophenotyping and Genetics Data sections below, and the instructions in the Hematopoietic Manual for further guidance on assigning Diagnostic confirmation. Alternate NamesDefinitionDefinitive Diagnostic MethodsGenetic testing Histologic confirmation Immunophenotyping Genetics DataDysregulation of CDK6 gene at 7q21 Immunoglobulin heavy and light chain rearrangement ImmunophenotypingAnnexin A1 neg CD5- CD10- CD20+ CD23- CD43- CD79a+ CD103- Cyclin D1 absent Ki-67 staining shows distinctive targetoid pattern LEF1 absent Surface IgD Surface IgM TreatmentsChemotherapy Immunotherapy Surgery Transformations toTransformations fromNone Same PrimariesCorresponding ICD-9 Codes200.3 Marginal zone lymphoma Corresponding ICD-10 CodesC83.0 Non-Hodgkin lymphoma small cell (diffuse) Corresponding ICD-10-CM Codes (U.S. only)C83.0 Small cell B-cell lymphoma (effective October 01, 2015) Signs and SymptomsAnemia Drenching night sweats Fatigue Fever (for no known reason) Pain in the chest, abdomen, or bones (for no known reason) Skin rashes or itchy skin Splenomegaly Weight loss (for no known reason) Diagnostic ExamsFlow cytometry Immunohistochemistry Immunophenotyping Splenectomy Progression and TransformationEpidemiology and MortalityAge: mostly 50 years and older Incidence: 2% of lymphoid neoplasms Sex: no male or female predominance SourcesSwerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds): International Classification of Diseases for Oncology, Third Edition, Second Revision. Geneva: World Health Organization, 2020. National Cancer Institute What is splenic marginal zone lymphoma?Splenic marginal zone lymphoma (SMZL) is a low-grade B-cell non-Hodgkin's lymphoma characterized by massive splenomegaly, moderate lymphocytosis with or without villous lymphocytes, rare involvement of peripheral lymph nodes and indolent clinical course.
What is splenic marginal zone B cell lymphoma?Splenic marginal zone lymphoma (SMZL) is a slow-growing (indolent) B-cell non-Hodgkin lymphoma (NHL). It usually affects the spleen, bone marrow and blood. It can sometimes affect lymph nodes in the abdomen, but in most cases SMZL doesn't affect lymph nodes.
Where is marginal zone lymphoma?SMZL arises predominantly from the marginal zone memory B-cells located in the follicles of the spleen, splenic hilar lymph nodes, BM, and the peripheral blood.
Is marginal zone lymphoma the same as MALT?MALT lymphoma is a slow-growing (low-grade) non-Hodgkin lymphoma that develops from B cells. It is a type of marginal zone lymphoma: a lymphoma that develops in a particular region at the edge of lymphoid tissues (collections of lymphocytes) called the marginal zone.
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